Randomized, Placebo-Controlled, Double-Blind Pilot Study of D-Cycloserine in Chronic Stroke

Table 3

ANCOVA table for (a) treatment group, (b) baseline performance effect, and (c) treatment group × baseline performance interaction for A-prime, reaction time, DETECT -score, grip strength, BBT, CES-D, and SIS categories. There was a significant main effect of treatment group on the SIS affected hand function domain. There was a significant main effect of baseline performance on CES-D score and SIS memory, mood, affected hand function, and social participation domain scores. There was a significant treatment group × baseline performance interaction for SIS affected hand function domain only.

(a) ANCOVA (per group)

Source			-RFDR
A-prime	0.003	0.959	1.812	0.000
Reaction time	0.041	0.844	1.594	0.005
DETECT -score	0.730	0.421	0.795	0.094
Grip strength, affected hand	0.829	0.386	0.730	0.084
Grip strength, unaffected hand	0.405	0.540	1.020	0.043
BBT, affected hand	0.111	0.747	1.410	0.012
BBT, unaffected hand	1.884	0.203	0.384	0.173
CES-D score	0.092	0.769	1.452	0.010
Stroke Impact Scale Category
Strength	0.342	0.573	1.083	0.037
Memory	5.414	0.045	0.085	0.376
Mood	0.855	0.379	0.716	0.087
Communication	1.755	0.218	0.412	0.163
ADL/IADL	0.005	0.947	1.788	0.001
Mobility	0.536	0.483	0.912	0.056
Hand function	12.054	0.007	0.013	0.573
Participation	3.483	0.095	0.179	0.279
Stroke recovery	1.006	0.342	0.616	0.101

(b) ANCOVA (per baseline) across all subjects

Source			-RFDR
A-prime	0.978	0.348	0.658	0.098
Reaction time	6.427	0.032	0.060	0.417
DETECT -score	4.256	0.078	0.147	0.378
Grip strength, affected hand	1.487	0.254	0.479	0.142
Grip strength, unaffected hand	1.541	0.246	0.464	0.146
BBT, affected hand	0.001	0.975	1.842	0.000
BBT, unaffected hand	5.576	0.043	0.080	0.383
CES-D score	15.197	0.004	0.007	0.628
Stroke Impact Scale Category
Strength	5.803	0.039	0.074	0.392
Memory	19.591	0.002	0.003	0.685
Mood	8.484	0.017	0.033	0.485
Communication	0.971	0.350	0.662	0.097
ADL/IADL	4.477	0.063	0.120	0.332
Mobility	0.934	0.359	0.678	0.094
Hand function	12.413	0.006	0.011	0.580
Participation	9.292	0.014	0.026	0.508
Stroke recovery	5.645	0.041	0.074	0.385

(c) ANCOVA (group baseline interaction)

Source			-RFDR
A-prime	0.001	0.980	1.852	0.000
Reaction time	0.024	0.879	1.661	0.003
DETECT -score	0.725	0.423	0.798	0.094
Grip strength, affected hand	0.009	0.926	1.750	0.001
Grip strength, unaffected hand	0.381	0.553	1.044	0.041
BBT, affected hand	0.724	0.417	0.787	0.074
BBT, unaffected hand	1.531	0.247	0.467	0.145
CES-D score	0.835	0.385	0.726	0.085
Stroke Impact Scale Category
Strength	0.202	0.663	1.253	0.022
Memory	3.667	0.088	0.166	0.290
Mood	1.082	0.325	0.615	0.107
Communication	1.423	0.263	0.498	0.136
ADL/IADL	0.025	0.877	1.656	0.003
Mobility	0.450	0.519	0.981	0.048
Hand function	11.771	0.007	0.013	0.567
Participation	3.882	0.080	0.151	0.301
Stroke recovery	0.302	0.596	1.073	0.032