Differential Effects of Alpha-Particle Radiation and X-Irradiation on Genes Associated with Apoptosis

Table 1

Functional gene groupings.

Functional families	Gene symbol
TNF ligand	CD40LG, FASLG, LTA, TNF, TNFSF10, CD70, TNFSF8
TNF receptor	CD40, FAS, LTBR, TNFRSF10A, TNFRSF10B, TNFRS11B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, CD27, TNFRSF9
BCL-2	BAD, BAG1, BAG3, BAK4, BAX, BCL2, BCL2A1, BCL2L1, BCl2L10, BCL2L11, BCL2L2, BCLAF1, BID, BIK, BNIP1, BNIP2, BNIP3, BNIP3L, HRK, MCL1
Caspase	CASP1, CASP10, CASP14, CASP2, CASP3, CASP4, CASP5, CASP6, CASP7, CASP8, CASP9,
IAP	NAIP, BIRC2, BIRC3, BIRC4, BIRC6, BIRC8
TRAF	TRAF2, TRAF3, TRAF4
CARD	APAF1, BCL10, BIRC2, BIRC3, NOD1, CARD6, CARD8, CASP1, CASP2, CASP4, CASP5, CASP9
Death domain	CRADD, DAPK1, FADD, FAS, TNFRSF10A, TNFRSF10B, TNFRSF11B, TNFRSF1A, TNFRSF21, TNFRSF25, TRADD
Death effector domain	CASP8, CASP10, CFLAR, FADD
CIDE domain	CIDEA, CIDEB, DFFA
P53 and DNA damage response	ABL1, AKT1, APAF1, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, GADD45A, TP53, TP53BP2, TP73
Anti-apoptosis	AKT1, BAG1, BAG3, BCL2, BCL2A1, BCl2L1, BCl2L10, BCL2L2L, BFAR, NAIP, BIRC2, BIRC3, BIRC4, BIRC6, BIRC8, BNIP1, BNIP2, BNIP3, BRAF, CASP2, CFLAR, FAS, IGF1R, MCL1, TNF, CDC27