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Radiology Research and Practice
Volume 2012, Article ID 203538, 5 pages
Clinical Study

Double Bolus Application in TWIST-MR-Angiography of the Cervical Arteries

Department of Diagnostic and Interventional Neuroradiology, University of Tübingen, Hoppe-Seyler Street 3, 72076 Tübingen, Germany

Received 19 July 2012; Revised 2 October 2012; Accepted 2 October 2012

Academic Editor: Paul Sijens

Copyright © 2012 Andreas Korn et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. The aim of the present work was to test the feasibility of the time-resolved MR-angiography (TWIST-MRA) of cervical arteries using double bolus injection. Material and Methods. TWIST-MRA with a temporal resolution of 8.4 seconds for each frame and a spatial resolution with a voxel size of was performed in 24 patients. A biphasic bolus injection protocol was used with the second injection being started 21 seconds after the first contrast dye bolus. Diagnostic image quality was rated according to a 4-point scale. Results. In 12 patients (50%) no clear separation between the cervical venous and arterial vessels was evident after the first bolus injection. Using TWIST-MRA data acquired after the second bolus a sufficient diagnostic image quality (rating , mean 3.5) could be obtained in 22 of 24 patients (92%). Discussion. The double bolus injection protocol using TWIST-MRA allows for very good separation of the cervical arteries.