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Radiology Research and Practice
Volume 2013, Article ID 628150, 7 pages
Clinical Study

Hepatic Iron Quantification on 3 Tesla (3 T) Magnetic Resonance (MR): Technical Challenges and Solutions

1Department of Pediatric Radiology, Children’s Hospital at Montefiore, Bronx, NY, USA
2Department of Pediatric Radiology, Children’s Hospital Los Angeles, Los Angeles, CA, USA
3Division of Pediatric Cardiology, Children’s Hospital Los Angeles, Los Angeles, CA, USA
4Department of Pediatrics, Division of Pediatric Hematology/Oncology, Children’s Hospital at Montefiore, Bronx, NY, USA
5Department of Pediatrics, Division of General Pediatrics, Children’s Hospital at Montefiore, Bronx, NY, USA

Received 23 January 2013; Revised 19 April 2013; Accepted 19 April 2013

Academic Editor: Paul Sijens

Copyright © 2013 Muhammad Anwar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


MR has become a reliable and noninvasive method of hepatic iron quantification. Currently, most of the hepatic iron quantification is performed on 1.5 T MR, and the biopsy measurements have been paired with and values for 1.5 T MR. As the use of 3 T MR scanners is steadily increasing in clinical practice, it has become important to evaluate the practicality of calculating iron burden at 3 T MR. Hepatic iron quantification on 3 T MR requires a better understanding of the process and more stringent technical considerations. The purpose of this work is to focus on the technical challenges in establishing a relationship between values at 1.5 T MR and 3 T MR for hepatic iron concentration (HIC) and to develop an appropriately optimized MR protocol for the evaluation of values in the liver at 3 T magnetic field strength. We studied 22 sickle cell patients using multiecho fast gradient-echo sequence (MFGRE) 3 T MR and compared the results with serum ferritin and liver biopsy results. Our study showed that the quantification of hepatic iron on 3 T MRI in sickle cell disease patients correlates well with clinical blood test results and biopsy results. 3 T MR liver iron quantification based on MFGRE can be used for hepatic iron quantification in transfused patients.