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Radiology Research and Practice
Volume 2014, Article ID 871619, 10 pages
http://dx.doi.org/10.1155/2014/871619
Research Article

Multisite Kinetic Modeling of 13C Metabolic MR Using [1-13C]Pyruvate

1GE Global Research, 85748 Garching bei München, Germany
2Medical Engineering, Tecnológico de Monterrey, 64849 Monterrey, NL, Mexico
3Medical Engineering, Technische Universität München, 85748 Garching bei München, Germany
4Nuclear Medicine, Technische Universität München, 81675 Munich, Germany
5Chemistry, Technische Universität München, 85748 Garching bei München, Germany

Received 30 August 2014; Revised 6 November 2014; Accepted 13 November 2014; Published 8 December 2014

Academic Editor: David Maintz

Copyright © 2014 Pedro A. Gómez Damián et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. M. Brindle, “NMR methods for measuring enzyme kinetics in vivo,” Progress in Nuclear Magnetic Resonance Spectroscopy, vol. 20, no. 3, pp. 257–293, 1988. View at Publisher · View at Google Scholar · View at Scopus
  2. J. H. Ardenkjær-Larsen, B. Fridlund, A. Gram et al., “Increase in signal-to-noise ratio of >10,000 times in liquid-state NMR,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 18, pp. 10158–10163, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. K. Golman, R. In 't Zandt, and M. Thaning, “Real-time metabolic imaging,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 30, pp. 11270–11275, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. M. E. Bizeau, C. Short, J. S. Thresher, S. R. Commerford, W. T. Willis, and M. J. Pagliassotti, “Increased pyruvate flux capacities account for diet-induced increases in gluconeogenesis in vitro,” American Journal of Physiology, vol. 281, no. 2, pp. R427–R433, 2001. View at Google Scholar · View at Scopus
  5. M. A. Janich, M. I. Menzel, F. Wiesinger et al., “Effects of pyruvate dose on in vivo metabolism and quantification of hyperpolarized 13C spectra,” NMR in Biomedicine, vol. 25, no. 1, pp. 142–151, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. H. J. Atherton, M. A. Schroeder, M. S. Dodd et al., “Validation of the in vivo assessment of pyruvate dehydrogenase activity using hyperpolarised 13C MRS,” NMR in Biomedicine, vol. 24, no. 2, pp. 201–208, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. S. E. Day, M. I. Kettunen, F. A. Gallagher et al., “Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy,” Nature Medicine, vol. 13, no. 11, pp. 1382–1387, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. M. L. Zierhut, Y.-F. Yen, A. P. Chen et al., “Kinetic modeling of hyperpolarized 13C1-pyruvate metabolism in normal rats and TRAMP mice,” Journal of Magnetic Resonance, vol. 202, no. 1, pp. 85–92, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. D. M. Spielman, D. Mayer, Y.-F. Yen, J. Tropp, R. E. Hurd, and A. Pfefferbaum, “In vivo measurement of ethanol metabolism in the rat liver using magnetic resonance spectroscopy of hyperpolarized [1-13C]pyruvate,” Magnetic Resonance in Medicine, vol. 62, no. 2, pp. 307–313, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. O. Khegai, R. F. Schulte, M. A. Janich et al., “Apparent rate constant mapping using hyperpolarized [1–13C]pyruvate,” NMR in Biomedicine, vol. 27, no. 10, pp. 1256–1265, 2014. View at Publisher · View at Google Scholar
  11. J. M. Park, S. Josan, T. Jang et al., “Metabolite kinetics in C6 rat glioma model using magnetic resonance spectroscopic imaging of hyperpolarized [1-13C]pyruvate,” Magnetic Resonance in Medicine, vol. 68, no. 6, pp. 1886–1893, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. S. Josan, D. Spielman, Y.-F. Yen, R. Hurd, A. Pfefferbaum, and D. Mayer, “Fast volumetric imaging of ethanol metabolism in rat liver with hyperpolarized [1-13C]pyruvate,” NMR in Biomedicine, vol. 25, no. 8, pp. 993–999, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. M. I. Kettunen, D.-E. Hu, T. H. Witney et al., “Magnetization transfer Measurements of exchange between hyperpolarized [1-13C]pyruvate and [1-13C]lactate in a murine lymphoma,” Magnetic Resonance in Medicine, vol. 63, no. 4, pp. 872–880, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. P. E. Z. Larson, A. B. Kerr, C. Leon Swisher, J. M. Pauly, and D. B. Vigneron, “A rapid method for direct detection of metabolic conversion and magnetization exchange with application to hyperpolarized substrates,” Journal of Magnetic Resonance, vol. 225, pp. 71–80, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. C. Harrison, C. Yang, A. Jindal et al., “Comparison of kinetic models for analysis of pyruvate-to-lactate exchange by hyperpolarized 13C NMR,” NMR in Biomedicine, vol. 25, no. 11, pp. 1286–1294, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. D. K. Hill, M. R. Orton, E. Mariotti et al., “Model free approach to kinetic analysis of real-time hyperpolarized 13C magnetic resonance spectroscopy data,” PLoS ONE, vol. 8, no. 9, Article ID e71996, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. L. Z. Li, S. Kadlececk, H. N. Xu et al., “Ratiometric analysis in hyperpolarized NMR (I): test of the two-site exchange model and the quantification of reaction rate constants,” NMR in Biomedicine, vol. 26, no. 10, pp. 1308–1320, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. F. A. Gallagher, M. I. Kettunen, and K. M. Brindle, “Biomedical applications of hyperpolarized 13C magnetic resonance imaging,” Progress in Nuclear Magnetic Resonance Spectroscopy, vol. 55, no. 4, pp. 285–295, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. M. F. Santarelli, V. Positano, G. Giovannetti et al., “How the signal-to-noise ratio influences hyperpolarized 13C dynamic MRS data fitting and parameter estimation,” NMR in Biomedicine, vol. 25, no. 7, pp. 925–934, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. M. E. Merritt, C. Harrison, C. Storey, F. M. Jeffrey, A. D. Sherry, and C. R. Malloy, “Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 50, pp. 19772–19777, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. S. M. Kazan, S. Reynolds, A. Kennerley et al., “Kinetic modeling of hyperpolarized 13C pyruvate metabolism in tumors using a measured arterial input function,” Magnetic Resonance in Medicine, vol. 70, no. 4, pp. 943–953, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. C. Yang, C. Harrison, E. S. Jin et al., “Simultaneous steady-state and dynamic 13C NMR can differentiate alternative routes of pyruvate metabolism in living cancer cells,” The Journal of Biological Chemistry, vol. 289, no. 9, pp. 6212–6224, 2014. View at Publisher · View at Google Scholar · View at Scopus
  23. F. Wiesinger, I. Miederer, M. I. Menzel et al., “Metabolic rate constant mapping of hyperpolarized 13C pyruvate,” ISMRM 3282, 2010. View at Google Scholar
  24. L. Vanhamme, A. van den Boogaart, and S. van Huffel, “Improved method for accurate and efficient quantification of mrs data with use of prior knowledge,” Journal of Magnetic Resonance, vol. 129, no. 1, pp. 35–43, 1997. View at Publisher · View at Google Scholar · View at Scopus
  25. T. Harris, G. Eliyahu, L. Frydman, and H. Degani, “Kinetics of hyperpolarized 13C1-pyruvate transport and metabolism in living human breast cancer cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 43, pp. 18131–18136, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. T. Xu, D. Mayer, M. Gu et al., “Quantification of in vivo metabolic kinetics of hyperpolarized pyruvate in rat kidneys using dynamic 13C MRSI,” NMR in Biomedicine, vol. 24, no. 8, pp. 997–1005, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. J. D. Shearer, G. P. Buzby, J. L. Mullen, E. Miller, and M. D. Caldwell, “Alteration in pyruvate metabolism in the liver of tumor-bearing rats,” Cancer Research, vol. 44, no. 10, pp. 4443–4446, 1984. View at Google Scholar · View at Scopus
  28. D. M. Bates and D. G. Watts, Nonlinear Regression Analysis and Its Applications, John Wiley & Sons, New York, NY, USA, 2008. View at MathSciNet
  29. O. Warburg, “On the origin of cancer cells,” Science, vol. 123, no. 3191, pp. 309–314, 1956. View at Publisher · View at Google Scholar · View at Scopus
  30. H. Lu, R. A. Forbes, and A. Verma, “Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis,” The Journal of Biological Chemistry, vol. 277, no. 26, pp. 23111–23115, 2002. View at Publisher · View at Google Scholar · View at Scopus
  31. W. Droge, H.-P. Eck, H. Kriegbaum, and S. Mihm, “Release of L-alanine by tumor cells,” The Journal of Immunology, vol. 137, no. 4, pp. 1383–1386, 1986. View at Google Scholar · View at Scopus
  32. L. Brennan, C. Hewage, J. P. G. Malthouse, and G. J. McBean, “Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C NMR spectroscopic study,” Neurochemistry International, vol. 45, no. 8, pp. 1155–1165, 2004. View at Publisher · View at Google Scholar · View at Scopus
  33. H. R. Harding, F. Rosen, and C. A. Nichol, “Depression of Alanine Transaminase Activity in the Liver of Rats Bearing Walker Carcinoma 256,” Cancer Research, vol. 24, pp. 1318–1323, 1964. View at Google Scholar · View at Scopus
  34. S. M. Ronen, A. Volk, and J. Mispelter, “Comparative NMR study of a differentiated rat hepatoma and its dedifferentiated subclone cultured as spheroids and as implanted tumors,” NMR in Biomedicine, vol. 7, no. 6, pp. 278–286, 1994. View at Publisher · View at Google Scholar · View at Scopus