Imaging Modalities to Identity Inflammation in an Atherosclerotic Plaque

Figure 1

N1177-enhanced CT and corresponding FDG PET from atherosclerotic rabbit. Fused PET/CT coronal view of aorta obtained 3 hours after injection of 18F-labeled fluorodeoxyglucose (FDG) and corresponding axial aortic sections acquired before (b and d) and at 2 hours after injection of N1177, an iodine-based contrast agent that accumulates in macrophages (c and e). Aortic regions with high ((a), red cross) and low ((a), white cross) activities identified with PET at 3 hours after injection of FDG were associated with strong ((e), red cross) and weak ((c), white cross) intensities of enhancement detected in CT at 2 hours after injection of N1177 on corresponding axial views, respectively. Reprinted with permission from Hyafil et al. [20].