Automated Determination of Arterial Input Function for Dynamic Susceptibility Contrast MRI from Regions around Arteries Using Independent Component Analysis

Table 1

Comparisons of time-to-peak (TTP), arrival time (the first time point above the mean time response), FWHM, and peak high after gamma fitting in 8 subjects as determined by manual ROI (Manu-roi) and ICA in artery (ICA-aw) and surrounding tissue (ICA-sw). Below the table, there is statistic comparison with paired -test for manual and weighted-ICA ROI. Significant difference between Manu-roi and ICA-aw ROI is found in TTP, onset time, and peak high and that between Manu-roi and ICA-sw ROI is found in TTP, onset time, FWHM, and peak. For ICA-aw and ICA-sw, there are significant differences in onset time, FWHM, and peak high.

	TTP (sec)			Onset time (sec)			FWHM (sec)			Peak high (#/mL)
	Manu-roi	ICA-aw	ICA-sw	Manu-roi	ICA-aw	ICA-sw	Manu-roi	ICA-aw	ICA-sw	Manu-roi	ICA-aw	ICA-sw
#1 (36 y, m)	26.70	25.89	26.07	21.12	19.64	21.89	7.650	7.305	5.775	546.6	1423	324.4
#2 (33 y, m)	29.36	27.66	27.98	20.94	20.55	21.68	9.615	8.295	7.365	528.4	1020	456.5
#3 (32 y, m)	28.20	27.20	27.27	21.09	20.01	22.67	9.450	9.375	7.005	421.6	1077	337.3
#4 (46 y, m)	26.58	27.81	27.50	21.42	20.97	22.37	6.495	7.830	6.885	401.4	960.2	305.9
#5 (35 y, f)	24.74	24.18	24.03	18.68	18.60	19.08	9.060	8.655	6.090	427.8	792.2	508.3
#6 (35 y, f)	22.69	22.16	21.71	18.24	17.48	17.67	6.960	7.515	5.865	438.0	671.2	463.1
#7 (38 y, f)	30.50	29.41	29.58	22.85	22.88	25.73	12.53	9.240	4.920	422.3	903.7	309.9
#8 (29 y, f)	27.25	26.42	26.37	20.15	19.00	22.37	11.12	9.855	4.380	361.2	1033	411.1
Mean	27.00	26.34	26.31	20.56	19.89	21.68	9.110	8.509	6.036	443.4	985.0	389.6
Std	2.487	2.281	2.456	1.503	1.642	2.427	2.060	0.931	1.036	62.78	222.6	79.98

Significantly (, paired -test) higher than Manu-roi.
Significantly (, paired -test) higher than ICA-aw.
Standard deviation.