Table of Contents Author Guidelines Submit a Manuscript
Table of Contents Alerts

To receive news and publication updates for Radiology Research and Practice, enter your email address in the box below.

Radiology Research and Practice
Volume 2016 (2016), Article ID 9305018, 7 pages
http://dx.doi.org/10.1155/2016/9305018
Research Article

Novel Pattern of Iron Deposition in the Fascicula Nigrale in Patients with Parkinson’s Disease: A Pilot Study

Miriam E. Peckham,1 Khashayar Dashtipour,2 Barbara A. Holshouser,1 Camellia Kani,2 Alex Boscanin,1 Kayvan Kani,1 and Sheri L. Harder1

1Department of Radiology, School of Medicine, Loma Linda University, 11234 Anderson Street, Loma Linda, CA 92354, USA
2Department of Neurology, School of Medicine, Loma Linda University, 11234 Anderson Street, Loma Linda, CA 92354, USA

Received 7 March 2016; Revised 31 May 2016; Accepted 31 May 2016

Academic Editor: Paul Sijens

Copyright © 2016 Miriam E. Peckham et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. K. Dreyer, “Three mechanisms by which striatal denervation causes breakdown of dopamine signaling,” The Journal of Neuroscience, vol. 34, no. 37, pp. 12444–12456, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. A. K. Lotfipour, S. Wharton, S. T. Schwarz et al., “High resolution magnetic susceptibility mapping of the substantia nigra in Parkinson's disease,” Journal of Magnetic Resonance Imaging, vol. 35, no. 1, pp. 48–55, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. S. L. Harder, K. M. Hopp, H. Ward, H. Neglio, J. Gitlin, and D. Kido, “Mineralization of the deep gray matter with age: a retrospective review with susceptibility-weighted MR imaging,” American Journal of Neuroradiology, vol. 29, no. 1, pp. 176–183, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. E. S. Manova, C. A. Habib, A. S. Boikov et al., “Characterizing the mesencephalon using susceptibility-weighted imaging,” American Journal of Neuroradiology, vol. 30, no. 3, pp. 569–574, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. J. M. Graham, M. N. J. Paley, R. A. Grünewald, N. Hoggard, and P. D. Griffiths, “Brain iron deposition in Parkinson's disease imaged using the PRIME magnetic resonance sequence,” Brain, vol. 123, part 12, pp. 2423–2431, 2000. View at Publisher · View at Google Scholar · View at Scopus
  6. K. Dashtipour, M. Liu, C. Kani et al., “Iron accumulation is not homogenous among patients with Parkinson's disease,” Parkinson's Disease, vol. 2015, Article ID 324843, 8 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  7. D. W. Lee and J. K. Andersen, “Iron elevations in the aging Parkinsonian brain: a consequence of impaired iron homeostasis?” Journal of Neurochemistry, vol. 112, no. 2, pp. 332–339, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. C. W. Olanow and M. B. H. Youdim, “Iron and neurodegeneration: prospects for neuroprotection,” in Neurodegeneration and Neuroprotection in Parkinson's Disease, chapter 4, pp. 55–67, Academic Press, London, UK, 1996. View at Google Scholar
  9. T. Moos, N. Bernth, Y. Courtois, and E. H. Morgan, “Developmental iron uptake and axonal transport in the retina of the rat,” Molecular and Cellular Neuroscience, vol. 46, no. 3, pp. 607–613, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. E. C. Hirsch, “Altered regulation of iron transport and storage in Parkinson's disease,” Journal of neural transmission. Supplementum, no. 71, pp. 201–204, 2006. View at Google Scholar · View at Scopus
  11. E. C. Hirsch, “Iron transport in Parkinson's disease,” Parkinsonism and Related Disorders, vol. 15, supplement 3, pp. S209–S211, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. B. Hallgren and P. Sourander, “The effect of age on the non-haemin iron in the human brain,” Journal of Neurochemistry, vol. 3, no. 1, pp. 41–51, 1958. View at Publisher · View at Google Scholar
  13. P. Péran, A. Cherubini, F. Assogna et al., “Magnetic resonance imaging markers of Parkinson's disease nigrostriatal signature,” Brain, vol. 133, no. 11, pp. 3423–3433, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Deistung, A. Schäfer, F. Schweser, U. Biedermann, R. Turner, and J. R. Reichenbach, “Toward in vivo histology: a comparison of quantitative susceptibility mapping (QSM) with magnitude-, phase-, and R2∗-imaging at ultra-high magnetic field strength,” NeuroImage, vol. 65, pp. 299–314, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. E. M. Haacke, S. Liu, S. Buch, W. Zheng, D. Wu, and Y. Ye, “Quantitative susceptibility mapping: current status and future directions,” Magnetic Resonance Imaging, vol. 33, no. 1, pp. 1–25, 2015. View at Publisher · View at Google Scholar · View at Scopus
  16. J. Zhang, Y. Zhang, J. Wang et al., “Characterizing iron deposition in Parkinson's disease using susceptibility-weighted imaging: an in vivo MR study,” Brain Research, vol. 1330, pp. 124–130, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. Y. Murakami, S. Kakeda, K. Watanabe et al., “Usefulness of quantitative susceptibility mapping for the diagnosis of Parkinson disease,” American Journal of Neuroradiology, vol. 36, no. 6, pp. 1102–1108, 2015. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Wieler, M. Gee, and W. R. W. Martin, “Longitudinal midbrain changes in early Parkinson's disease: iron content estimated from R2∗/MRI,” Parkinsonism and Related Disorders, vol. 21, no. 3, pp. 179–183, 2015. View at Publisher · View at Google Scholar · View at Scopus
  19. F. J. A. Meijer and B. Goraj, “Brain MRI in Parkinson's disease,” Frontiers in Bioscience, vol. 6, no. 2, pp. 360–369, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. P. Riederer, A. Dirr, M. Goetz, E. Sofic, K. Jellinger, and M. B. H. Youdim, “Distribution of iron in different brain regions and subcellular compartments in Parkinson's disease,” Annals of Neurology, vol. 32, supplement 1, pp. S101–S104, 1992. View at Publisher · View at Google Scholar · View at Scopus
  21. P. D. Griffiths, B. R. Dobson, G. R. Jones, and D. T. Clarke, “Iron in the basal ganglia in Parkinson's disease. An in vitro study using extended X-ray absorption fine structure and cryo-electron microscopy,” Brain, vol. 122, no. 4, pp. 667–673, 1999. View at Publisher · View at Google Scholar · View at Scopus
  22. D. T. Dexter, A. Carayon, F. Javoy-Agid et al., “Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia,” Brain, vol. 114, part 4, pp. 1953–1975, 1991. View at Publisher · View at Google Scholar · View at Scopus
  23. Y. Wang, S. R. Butros, X. Shuai et al., “Different iron-deposition patterns of multiple system atrophy with predominant parkinsonism and idiopathetic Parkinson diseases demonstrated by phase-corrected susceptibility-weighted imaging,” American Journal of Neuroradiology, vol. 33, no. 2, pp. 266–273, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. S. Haller, S. Badoud, D. Nguyen et al., “Differentiation between Parkinson disease and other forms of Parkinsonism using support vector machine analysis of susceptibility-weighted imaging (SWI): initial results,” European Radiology, vol. 23, no. 1, pp. 12–19, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. J. H. O. Barbosa, A. C. Santos, V. Tumas et al., “Quantifying brain iron deposition in patients with Parkinson's disease using quantitative susceptibility mapping, R2 and R2∗,” Magnetic Resonance Imaging, vol. 33, no. 5, pp. 559–565, 2015. View at Publisher · View at Google Scholar · View at Scopus
  26. E. M. Haacke, M. Makki, Y. Ge et al., “Characterizing iron deposition in multiple sclerosis lesions using susceptibility weighted imaging,” Journal of Magnetic Resonance Imaging, vol. 29, no. 3, pp. 537–544, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. E. M. Haacke, J. Tang, J. Neelavalli, and Y. C. Cheng, “Susceptibility mapping as a means to visualize veins and quantify oxygen saturation,” Journal of Magnetic Resonance Imaging, vol. 32, pp. 663–676, 2010. View at Google Scholar
  28. J. Tang, S. Liu, J. Neelavalli, Y. C. N. Cheng, S. Buch, and E. M. Haacke, “Improving susceptibility mapping using a threshold-based K-space/image domain iterative reconstruction approach,” Magnetic Resonance in Medicine, vol. 69, no. 5, pp. 1396–1407, 2013. View at Publisher · View at Google Scholar · View at Scopus