Predicting Molecular Subtypes of Breast Cancer with Mammography and Ultrasound Findings: Introduction of Sono-Mammometry Score

Table 5

Multivariate analysis of ultrasound and mammographic findings.

Imaging findings	Outcome variable	value	Odds ratio	Confidence interval
Noncalcified mass/focal asymmetry v/s mass with calcification/only microcalcifications	TNBC v/s non-TNBC	0.03	1.124	6.141–22.69
Mass shape round/oval v/s irregular	TNBC v/s non-TNBC	<0.01	2.443	4.836–27.382
Margins well-circumscribed/microlobulated v/s irregular spiculated	TNBC v/s non-TNBC	<0.01	2.472	1.462–6.479
Orientation parallel v/s nonparallel	TNBC v/s non-TNBC	0.03	1.176	1.100–9.562
Posterior enhancement v/s shadowing	TNBC v/s non-TNBC	<0.01	1.731	3.190–9.988
Round/oval shape + well-defined/microlobulated margins	TNBC v/s non-TNBC	<0.01	2.612	6.034–30.744
Well-circumscribed/microlobulated margins + presence of posterior enhancement + absence of posterior shadowing	TNBC v/s non-TNBC	<0.01	2.946	8.224–44.073
Tumor grade III v/s I/II	TNBC v/s Non-TNBC	<0.01	1.231	1.962–5.977
Ki-67 high (<14%) v/s low (<14%)	TNBC v/s non-TNBC	0.03	1.108	1.451–6.320
Mass with microcalcifications/only microcalcifications v/s noncalcified mass/focal asymmetry	Her-2 neu +ve v/s Her-2 neu –ve	<0.01	1.366	2.371–6.481
Irregular shape/margins v/s well-circumscribed margins	Her-2 neu +ve v/s Her-2 neu –ve	.009	.937	1.263–5.157
Mass with microcalcifications/only microcalcification + irregular margins	Her-2 neu +ve v/s Her-2 neu –ve	<0.01	1.278	2.145–6.004

TNBC: triple-negative breast cancer. Non-TNBC:non-triple-negative breast cancer.