Current Approaches for Image Fusion of Histological Data with Computed Tomography and Magnetic Resonance Imaging

Figure 1

An overview of the presented review concerning multimodal registration of 3D scans and 2D sections. The methods described here extend the classical histological workflow with 3D imaging before sectioning. Thus, image representations of the tissue are present in two modalities. The research considered is grouped according to the dimensionality of the addressed problem into slice-to-volume (2D ⟶ 3D), slice-to-slice (2D ⟶ 2D), and volume-to-volume (3D ⟶ 3D) registration. Each category is further subdivided into elastic and non-elastic algorithms. This results in a specialized selection of algorithms that match and remedy the corresponding severity of deformations introduced during the sectioning process.