Current Approaches for Image Fusion of Histological Data with Computed Tomography and Magnetic Resonance Imaging

Figure 6

Comparison of the results achieved by SegReg and intensity-based registration for mouse tibia tissue [35]. Stained histological images (von Kossa staining) (a) and CT-plane (b) of mouse bone tibia were matched using SegReg. For this example, both affine and elastic registration techniques were applied. (c) The outcome of the affine registration approach. (d) The result of elastic registration. The overall difference was portrayed in (e) with the corresponding difference in the registration vector field superimposed. Reprinted by permission from Informa UK Ltd: Taylor and Francis online computer methods in biomechanics and biomedical engineering, 18 : 15, 1658–1673, histology to μCT registration of 2D histological sections with 3D micro-CT datasets from small animal vertebrae and tibiae, Oleg Museyko, Robert Percy Marshall, Jing Lu, Andreas Hess, Georg Schett, Michael Amling, Willi A. Kalender, and Klaus Engelke, Copyright© 2014 Informa UK Limited.

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