Current Approaches for Image Fusion of Histological Data with Computed Tomography and Magnetic Resonance Imaging

Figure 7

Aligned histological slide and MRI-plan of human prostate tissue through the group-wise scheme proposed by [10]. A histological slice of human prostate tissue (a) was through the group-wise alignment matched with a candidate MRI plane (b) and then affinely registered (c). The dotted polygons in (a) and (c) represent cancer cell distributions marked by experts. Reprinted from computerized medical imaging and graphics, 35/7–8, Gaoyu Xiao, B Nicolas Bloch, Jonathan Chappelow, Elizabeth M Genega, Neil M Rofsky, Robert E Lenkinski, John Tomaszewski, Michael D Feldman, Mark and Rosen, Anant Madabhushi, determining histology-MRI slice correspondences for defining MRI-based disease signatures of prostate cancer, Pages 568–578, Copyright (2011), with permission from Elsevier.

(a)

(b)

(c)