Current Approaches for Image Fusion of Histological Data with Computed Tomography and Magnetic Resonance Imaging

Figure 9

3D-volume reconstruction based on subsequent image-to-image registration poses a challenge in the conservation of the geometric consistency of the sectioning tissue. In order to register a histological image with a scanned volume, the individual sections first need to be aligned together, e.g., the volume needs to be reconstructed while geometrical consistency is maintained. Consecutive registration of individual slices needs to be performed until the original shape of the sectioned tissue is reconstructed in silico. Subsequently, inconsistencies in the intensity can be accounted for.