Sarcoma

Research Article

Ewing’s Sarcoma as a Second Malignancy in Long-Term Survivors of Childhood Hematologic Malignancies

Table 2

Review of the published cases of the Ewing sarcoma following the therapy of the hematologic malignancy as a primary tumor.
NumberNr with genetic confirmation (any method)ReferencePub yearAge at Dx PTAge at Dx ESLatency (y) Primary cancerLocation ESMolecular testTreatment of the primary hematological malignancy
Anthracyclines, TopoII-INHVincaAlkylating agentAntimetaboliteOther drugsRthAdditional treatment
1 Meadows et al. [27]1977  5ALLNDND       
21Tilly et al. [26]198481911ALLSacrumKaryotypeDNRVCRDTIC PDCranial RT 24 Gy 
3 Anselmo et al. [34]199420277HLChest wallND       
42Zoubek et al. [28]199512208Anaplastic T LCLPelvisKaryotype RT-PCRVP16 CPA, MELMTX, Ara-C TBI 12 Gy SCT (auto)
5 Delgado-Chavez et al. [35]199522264HLChest wallND       
63Antillon et al. [29] 19977169ALLTibiaRT-PCRDNRVCR  PD, L-asp  
7 Aparicio et al. [30] 199831512ALLUlnaNDADRVCR 6-MP, MTX, Ara-CL-aspCranial RT 
8 11187AMLFibulaNDDNR, ADR, MTZ, VP16  6-MP, 6-TG, Ara-C   
9 Bisogno et al. [31] 2004473HLThoracic wallNDADRVBLDTIC  RT 20 Gy 
10 71811CMLThighND   HU TBI 9 Gy, SCT (allo)
11 Suarez et al. [36]2004891ALLChest wallNDARDVCRCPAMTX, 6-MP, Ara-CPD  
124Kim et al. [32]2005374ALLHumerusKaryotype RT-PCRADRVCRCPA6-TG, MTX, Ara-CPD, L-asp  
135Spunt et al. [33] 20069123LCLRibFISHADRVCRCPA PDRT 15 Gy 
1468168ALLTibiaRT-PCRDNR, VP16VCRCPA6-MP, MTX, Ara-CPD, L-asp  
15772316Small, noncleaved cell lymphomaRibFISHADRVCRCPAMTX, Ara-C   
16812175HLChest wallRT-PCRADR, BLEVBL MTXPD  
17 Khadwal et al. [37]20068102HLKneeNDADR, BLEVBL   RT 24 Gy 
189Osone et al. [38]200710166ALLUrinary bladderRT-PCRADRVCRCPAMTX, 6-TGPD, L-aspnone 
19 Renard et al. [39]201171912ALLNDNDNDNDNDNDNDNDND
2010Lim et al. [40]201320222BurkittAdrenal glandFISHADRVCRCPAMTX, Ara-CDEXA  
2111Hiramoto et al. [14]201357658B-LCLSoft tissue backRT-PCRDNRVCRCPA PD GCSF
14 more cases Applebaum
et al. [25]		2013NDNDNDNDNDNDNDNDNDNDNDNDND
3612Current series2016583Lymphoblastic lymphomaParavertebralRT-PCRADR CPA, IFOAra-C  
3713Current series201616214T-ALLBrainFISHDNRVCRCPAMTX, Ara-C, 6-MP, 6-TG RT 12 Gy 
3814Current series20169112T-ALLMandibleFISH, RT-PCRDNRVCRCPA MTX, Ara-C, 6-MP TBI RT 12 Gy 
DNR, daunorubicin; VP-16, etoposide; ADR, doxorubicin; ACT, actinomycin D; MTZ, mitoxantrone; BLE, bleomycin; VCR, vincristine; VBL, vinblastine; DTIC, dacarbazine; CPA, cyclophosphamide; MEL, melphalan; IFO, ifosfamide; MTX, methotrexate; Ara-C, cytarabine; 6-MP, 6-mercaptopurine; 6-TG, thioguanine; HU, hydroxyurea; PD, prednisone; L-asp, L-asparaginase; RT, radiotherapy; TBI, total body irradiation; SCT, stem cell transplantation. ND: no data.