Deep Functional and Molecular Characterization of a High-Risk Undifferentiated Pleomorphic Sarcoma

Figure 3

Probabilistic Target Inhibitor Map (PTIM) model of the PCB209 xenograft-derived chemical screen. Orange text indicate targets inhibited by ABY-737; blue text indicates targets inhibited by midostaurin. (a) Pediatric preclinical testing initiative (PPTI) 60 chemical screen informed PTIM. (b) RNA-seq + PPTI chemical screen informed PTIM. PTIM models were used to guide a portion of the larger PDX in vivo trial shown in Figure 2. Numbers listed in the individual boxes represent scaled sensitivity values, 1 being a highly sensitive target combination and 0 being an ineffective/resistant target combination.

(a)

(b)