Nonlinear Biomechanical Characteristics of Deep Deformation of Native RBC Membranes in Normal State and under Modifier Action

Figure 3

The influence of hemin on RBC membrane stiffness. (a) AFM images of RBCs, 3D image cells, 50 × 50 μm², of a single cell, 10 × 10 μm², of a membrane defect in the form of a grain domain, and its profile. (b) Experimental curves for one RBC control, for hemin H50, and for H80, and their approximation by the Hertz model. (c) Histograms of density of relative frequency of Young’s modulus for control, H50, and H80, approximated by the normal law of the Gaussian distribution. (d) Distribution function of Young’s modulus (approximation by the normal Gaussian law) for the control and after the influence of H50 and H80.

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