Nonlinear Biomechanical Characteristics of Deep Deformation of Native RBC Membranes in Normal State and under Modifier Action

Figure 5

The process of RBC membrane bending under a probe action, and the construction of functions . (a) Experimental curves for highly stiff substance (glass), membranes of cells 1 and 2. (b) Experimental curves for cell membranes 1 and 2. (c) Bending of membranes under the action of force for stiff (1) and soft (2) membranes; is the force acting on the membrane from the probe, is the vertical displacement of the piezoscanner, is the depth of the membrane bending into RBC, PBS is the phosphate buffer solution, and is the bending radius of the membrane. (d) Gaussian probability density functions of RBC membrane Young’s modulus , for 8 healthy donors. (e) The experimental curve for one control (normal) RBC, its approximation by the Hertz model, and the polynomial .

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