Nonlinear Biomechanical Characteristics of Deep Deformation of Native RBC Membranes in Normal State and under Modifier Action

Figure 6

Influence of glutaraldehyde on RBC membrane stiffness. (a) AFM images of RBC, 50 × 50 μm² and 10 × 10 μm², after the action of 0.2% and 1% glutaraldehyde and their profiles, respectively. (b) Experimental curves for control cell, for cell after GA0.2%, and for GA1% action, and their approximation by the Hertz model. (c) Histograms of the relative frequency density for control RBCs and under the action of GA 0.2% and GA1% on cells, approximated by the normal law of the Gaussian distribution. (d) Distribution functions of Young’s modulus (approximation by the normal Gaussian law), for control and action of GA 0.2% and GA1%, correspondingly.

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