AFM and FluidFM Technologies: Recent Applications in Molecular and Cellular Biology

Figure 6

Schematic representation of the experimental procedure of the single-cell metabolic analysis using FluidFM and MALDI-TOF mass spectrometry. (a) Metabolite sampling using FluidFM. (b) Distribution of the cytoplasmic extract onto a selected MAMS spot. (c) Spraying of the 9AA matrix. (d) Acquisition of MS spectra. Adapted with permission from [31], copyright 2017 American Chemical Society.

(a)

(b)

(c)

(d)