Reactions of Subcutaneous Connective Tissue to Mineral Trioxide Aggregate, Biodentine®, and a Newly Developed BioACTIVE Base/Liner

Table 2

Number of samples with oedema, inflammation, fibrous capsule, calcification, and necrosis scores on days 7, 30, and 60.

		Control				ACTIVA BioACTİVE Base/Liner				ProRoot MTA				Biodentine®
Time		0	1	2	3	0	1	2	3	0	1	2	3	0	1	2	3
7 days	Calcification	7	—			4	3			5	2			5	2
	Necrosis	7	—			7	—			7	—			7	—
	Oedema	2	5	—	—	—	7	—	—	5	1	1	—	—	7	—	—
	Inflammation	0	5	2	—	—	1	5	1		1	5	1	—	4	3	—
	Fibrous capsule		7	—			3	4			3	4			1	6
30 days	Calcification	7	—			4	3			—	7			2	5
	Necrosis	7	—			7	—			7	—			7	—
	Oedema	7	—	—	—	4	3			4	3			7
	Inflammation	5	2	—	—	1	6			3	4			4	3
	Fibrous capsule		—	7			—	7			—	7			—	7
60 days	Calcification	7	—			2	5			—	7			2	5
	Necrosis	7	—			7	—			7	—			7	—
	Oedema	7	—	—	—	4	3	—	—	5	2	—	—	7	—	—	—
	Inflammation	7	—	—	—	5	2	—	—	6	1	—	—	6	1	—	—
	Fibrous capsule		—	7			—	7			—	7			—	7

Oedema (0 = absent, 1 = mild, 2 = moderate, and 3 = severe), inflammatory response (0 = absent, 1 = mild, 2 = moderate, and 3 = severe), fibrous capsule (1 = thin at <150 μm and 2 = thick at >150 μm), calcification (0 = absent and 1 = present), and necrosis (0 = absent and 1 = present).