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Stem Cells International
Volume 2010, Article ID 532704, 8 pages
Research Article

Noncultured Autologous Adipose-Derived Stem Cells Therapy for Chronic Radiation Injury

1Department of Plastic and Reconstructive Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan
2Takashi Nagai Memorial International Hibakusha Medical Center, Nagasaki University Hospital, Nagasaki 852-8501, Japan
3Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan
4Wolrd Health Organization, Geneva 27, Switzerland

Received 7 June 2010; Revised 4 August 2010; Accepted 28 September 2010

Academic Editor: Kotaro Yoshimura

Copyright © 2010 Sadanori Akita et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Increasing concern on chronic radiation injuries should be treated properly for life-saving improvement of wound management and quality of life. Recently, regenerative surgical modalities should be attempted with the use of noncultured autologous adipose-derived stem cells (ADSCs) with temporal artificial dermis impregnated and sprayed with local angiogenic factor such as basic fibroblast growth factor, and secondary reconstruction can be a candidate for demarcation and saving the donor morbidity. Autologous adipose-derived stem cells, together with angiogenic and mitogenic factor of basic fibroblast growth factor and an artificial dermis, were applied over the excised irradiated skin defect and tested for Patients who were uneventfully healed with minimal donor-site morbidity, which lasts more than 1.5 years.