Review Article
Phases I–III Clinical Trials Using Adult Stem Cells
Table 4
Randomized clinical trials in patients with chronic myocardial ischemia.
| | Trial | | Cell type | Delivery | Timing | Primary endpoint | Comments |
| | Losordo [24] | 24 | CD34+ | transendo | chronic | Improved angina parameters | No clear perfusion benefit | | PROTECT-CAD [25] | 28 | BMMC | transendo | chronic | Improved angina parameters | Improved LVEF and perfusion | | Van Ramshorst [26] | 50 | BMMC | transendo | chronic | Improved angina parameters | Improved LVEF and perfusion |
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BMMC: bone marrow mononuclear cells; LVEF: left ventricular ejection fraction.
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