Alteration in Marrow Stromal Microenvironment and Apoptosis Mechanisms Involved in Aplastic Anemia: An Animal Model to Study the Possible Disease Pathology
Figure 5
Phenotypical characterization of Sca1 and c-kit (CD-117) receptor expression by the bone marrow cells from normal (a) and Aplastic Anemic group (b) showed a quantitative depression in the primitive stem cell population in aplastic anemia. Phenotypical characterization of stromal progenitor cell marker (Sca1 and CD44) expression by the normal (c) and aplastic (d) bone marrow cells depicted depletion in the stromal progenitor cell population in aplastic anemia.
