Alteration in Marrow Stromal Microenvironment and Apoptosis Mechanisms Involved in Aplastic Anemia: An Animal Model to Study the Possible Disease Pathology
Figure 7
Flowcytometric analysis of intracellular apoptosis inducer proteins levels in normal and aplastic bone marrow cells. (a) Aplastic bone marrow cells (blue line) labeled with p-ASK1 showed a significant increase in median value of fluorescence intensity compared to the normal (red line). (b) Aplastic bone marrow cells (green line) labeled with phospho-JNK documented a significant increase in median value of fluorescence intensity in comparison with the normal (red line). (c) Aplastic bone marrow cells (blue line) labeled with cleaved caspase-3 documented convincing increase in median value of fluorescence intensity as compared to the normal (red line).
