Human Motor Neuron Progenitor Transplantation Leads to Endogenous Neuronal Sparing in 3 Models of Motor Neuron Loss

Figure 5

hMNP transplantation spares endogenous neurons. (a) Comparison of NeuN positive cells in cranial (𝑛=13 hMNP; 𝑛=15 vehicle) and caudal (𝑛=14 hMNP; 𝑛=15 vehicle) transverse sections in SCI animals. (b) Comparison of ChAT positive cells in cranial (𝑛=10 hMNP; 𝑛=12 vehicle) and caudal (𝑛=9 hMNP; 𝑛=12 vehicle) transverse sections of ventral horns in SCI animals. (c) Comparison of NeuN positive cells in cranial transverse sections of SOD1 G93A animals (𝑛=5 hMNP; 𝑛=5 vehicle). (d) Comparison of NeuN positive cells in cranial (𝑛=3 hMNP; 𝑛=3 vehicle) and caudal (𝑛=3 hMNP; 𝑛=2 vehicle) transverse sections of Δ7SMN animals. NeuN stained histological sections of lumbar spinal cord from hMNP (e) and vehicle (f) injected into SOD1 G93A mice clearly show a difference in neuronal numbers. Data is expressed as mean ± standard error. ^∗𝑃<.05. Bar = 50 μm.

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