Stem Cells International / 2011 / Article / Tab 1

Review Article

Cardiac Differentiation of Pluripotent Stem Cells

Table 1

Summary of prevalent cardiac differentiation methods.

Method descriptionDifferentiation efficiency %Stem cell typeReference

Spontaneous embryoid body method<10%hESC
hiPSC
Kehat et al. [6]
Zhang et al. [12]
END-2 method
Insulin depletion, PGI2, p38 MAPK inhibition
20%–25%hESC
hiPSC
Passier et al. [68], Graichen et al. [71]
Freund et al. [70]
Guided differentiation method
Activin A, BMP4
>30%hESC
hiPSC
Laflamme et al. [27]
Takahashi et al. [17]
Guided differentiation method
Activin A, BMP4, bFGF, VEGF, Dkk-1
40%–50%hESCYang et al. [57]

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