Vascular Guidance: Microstructural Scaffold Patterning for Inductive Neovascularization
Figure 6
(a) Experimental scaffolds explanted after 3 weeks in vivo show evidence of blood vessel formation (red, marked *) with surrounding connective tissue (blue areas). These areas together represent a vascular channel that was prefabricated within the PCL-HA scaffold. Clear areas occupied by surrounding PCL-HA scaffold fibers are marked with an “X”. (b) Multiple capillaries (red, marked with *) are also seen in areas of connective tissue, indicating extensive neovascularization. (c) In contrast, control scaffolds only show granulation tissue without evidence of significant neovascularization.
