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Stem Cells International
Volume 2011 (2011), Article ID 943216, 10 pages
Review Article

Could Metabolic Syndrome, Lipodystrophy, and Aging Be Mesenchymal Stem Cell Exhaustion Syndromes?

1Tissue Engineering, Regenerative Medicine and Cell Therapies Laboratory, CUCAIBA, Ministry of Health, Province of Buenos Aires, 1900 La Plata, Argentina
2Lipid Clinic, Division of Endocrinology, Hospital Clinic, 08036 Barcelona, Spain
3Division of Endometrial Regenerative Stem Cells, Medistem Inc., San Diego, CA 92122, USA
4Division of Cardiothoracic Surgery, University of Utah, Salt Lake City, UT 84132, USA
5Division Skin Bank, Burns Hospital, Buenos Aires City, C1424BSD, Argentina
6LNK Chemsolutions, Division of Nanotechnology, Lincoln, NE 68521, USA
7Bio-Target, Division of Nanotechnology, NE 68339, USA
8The University of Chicago, Division of Nanotechnology, Chicago, IL 60637, USA
9Nanovogue Inc., Division of Intelligent Matrices, Chicago, IL 60126-2731, USA
10INCUCAI, Presidency, Ministry of Health, 2250-C1428BAJ Buenos Aires, Argentina
11Vrije Universiteit, Burns Division, 1081 HV Amsterdam, The Netherlands

Received 15 August 2010; Accepted 22 March 2011

Academic Editor: Jozef Bartunek

Copyright © 2011 Eduardo Mansilla et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


One of the most important and complex diseases of modern society is metabolic syndrome. This syndrome has not been completely understood, and therefore an effective treatment is not available yet. We propose a possible stem cell mechanism involved in the development of metabolic syndrome. This way of thinking lets us consider also other significant pathologies that could have similar etiopathogenic pathways, like lipodystrophic syndromes, progeria, and aging. All these clinical situations could be the consequence of a progressive and persistent stem cell exhaustion syndrome (SCES). The main outcome of this SCES would be an irreversible loss of the effective regenerative mesenchymal stem cells (MSCs) pools. In this way, the normal repairing capacities of the organism could become inefficient. Our point of view could open the possibility for a new strategy of treatment in metabolic syndrome, lipodystrophic syndromes, progeria, and even aging: stem cell therapies.