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Stem Cells International
Volume 2012, Article ID 263264, 7 pages
http://dx.doi.org/10.1155/2012/263264
Research Article

The Influence of Brightness on Functional Assessment by mfERG: A Study on Scaffolds Used in Retinal Cell Transplantation in Pigs

1Department of Ophthalmology, Glostrup Hospital, Copenhagen University Hospital, Nordre Ringvej 57, 2600 Glostrup, Denmark
2NuVention Solutions Inc., Valley View, OH 44125, USA
3Case Western Reserve University, Cleveland, OH 44106, USA
4Eye Pathology Institute, University of Copenhagen, 2100 Copenhagen, Denmark
5Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
6The Gavin Herbert Eye Institute and Stem Cell Research Center, University of California, Irvine, CA 92697, USA
7Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, Louisville, KY 40208, USA

Received 16 August 2011; Accepted 7 November 2011

Academic Editor: Budd A. Tucker

Copyright © 2012 A. T. Christiansen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. Klassen and B. Reubinoff, “Stem cells in a new light,” Nature Biotechnology, vol. 26, no. 2, pp. 187–188, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Tomita, E. Lavik, H. Klassen, T. Zahir, R. Langer, and M. J. Young, “Biodegradable polymer composite grafts promote the survival and differentiation of retinal progenitor cells,” Stem Cells, vol. 23, no. 10, pp. 1579–1588, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. K. Warfvinge, J. F. Kiilgaard, E. B. Lavik et al., “Retinal progenitor cell xenografts to the pig retina: morphologic integration and cytochemical differentiation,” Archives of Ophthalmology, vol. 123, no. 10, pp. 1385–1393, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. E. B. Lavik, H. Klassen, K. Warfvinge, R. Langer, and M. J. Young, “Fabrication of degradable polymer scaffolds to direct the integration and differentiation of retinal progenitors,” Biomaterials, vol. 26, no. 16, pp. 3187–3196, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. B. A. Tucker, S. M. Redenti, C. Jiang et al., “The use of progenitor cell/biodegradable MMP2-PLGA polymer constructs to enhance cellular integration and retinal repopulation,” Biomaterials, vol. 31, no. 1, pp. 9–19, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Yao, B. A. Tucker, X. Zhang, P. Checa-Casalengua, R. Herrero-Vanrell, and M. J. Young, “Robust cell integration from co-transplantation of biodegradable MMP2-PLGA microspheres with retinal progenitor cells,” Biomaterials, vol. 32, no. 4, pp. 1041–1050, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. S. R. Hynes and E. B. Lavik, “A tissue-engineered approach towards retinal repair: scaffolds for cell transplantation to the subretinal space,” Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 248, no. 6, pp. 763–778, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. M. V. Kyhn, J. F. Kiilgaard, A. G. Lopez, E. Scherfig, J. U. Prause, and M. la Cour, “The multifocal electroretinogram (mfERG) in the pig,” Acta Ophthalmologica Scandinavica, vol. 85, no. 4, pp. 438–444, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. R. Ejstrup, E. Scherfig, and M. la Cour, “Electrophysiological consequences of experimental branch retinal vein occlusion in pigs and the effect of dorzolamide,” Investigative Ophthalmology and Visual Science, vol. 52, no. 2, pp. 952–958, 2011. View at Publisher · View at Google Scholar
  10. L. D. Hubbard, R. P. Danis, M. W. Neider et al., “Brightness, contrast, and color balance of digital versus film retinal images in the age-related eye disease study 2,” Investigative Ophthalmology and Visual Science, vol. 49, no. 8, pp. 3269–3282, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. Shimada and M. Horiguchi, “Stray light-induced multifocal electroretinograms,” Investigative Ophthalmology and Visual Science, vol. 44, no. 3, pp. 1245–1251, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. D. C. Hood, “Assessing retinal function with the multifocal technique,” Progress in Retinal and Eye Research, vol. 19, no. 5, pp. 607–646, 2000. View at Publisher · View at Google Scholar · View at Scopus
  13. L. Lu, M. J. Yaszemski, and A. G. Mikos, “Retinal pigment epithelium engineering using synthetic biodegradable polymers,” Biomaterials, vol. 22, no. 24, pp. 3345–3355, 2001. View at Publisher · View at Google Scholar · View at Scopus
  14. A. C. R. Grayson, G. Voskerician, A. Lynn, J. M. Anderson, M. J. Cima, and R. Langer, “Differential degradation rates in vivo and in vitro of biocompatible poly(lactic acid) and poly(glycolic acid) homo-and co-polymers for polymeric drug-delivery microchip,” Journal of Biomaterials Science, Polymer Edition, vol. 15, no. 10, pp. 1281–1304, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS), “Scientific opinion on the re-evaluation of Brilliant Blue FCF (E 133) as a food additive,” EFSA Journal, vol. 8, no. 11, p. 1853, 2010. View at Publisher · View at Google Scholar
  16. M. V. Kyhn, J. F. Kiilgaard, E. Scherfig, J. U. Prause, and M. la Cour, “The spatial resolution of the porcine multifocal electroretinogram for detection of laser-induced retinal lesions,” Acta Ophthalmologica, vol. 86, no. 7, pp. 786–793, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. Y. F. Ng, H. H. L. Chan, P. H. W. Chu et al., “Pharmacologically defined components of the normal porcine multifocal ERG,” Documenta Ophthalmologica, vol. 116, no. 3, pp. 165–176, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. D. C. Hood, L. J. Frishman, S. Saszik, and S. Viswanathan, “Retinal origins of the primate multifocal ERG: implications for the human response,” Investigative Ophthalmology and Visual Science, vol. 43, no. 5, pp. 1673–1685, 2002. View at Google Scholar · View at Scopus
  19. D. C. Hood, J. G. Odel, C. S. Chen, and B. J. Winn, “The multifocal electroretinogram,” Journal of Neuro-Ophthalmology, vol. 23, no. 3, pp. 225–235, 2003. View at Publisher · View at Google Scholar
  20. P. Tanskanen, T. Kylma, B. Kommonen, and U. Karhunen, “Propofol influences the electroretinogram to a lesser degree than thiopentone,” Acta Anaesthesiologica Scandinavica, vol. 40, no. 4, pp. 480–485, 1996. View at Google Scholar · View at Scopus
  21. A. Hendrickson and D. Hicks, “Distribution and density of medium-and short-wavelength selective cones in the domestic pig retina,” Experimental Eye Research, vol. 74, no. 4, pp. 435–444, 2002. View at Publisher · View at Google Scholar · View at Scopus