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Stem Cells International
Volume 2012, Article ID 316281, 6 pages
Review Article

Tendon Regeneration and Repair with Stem Cells

1University of Manchester, Manchester M13 9PL, UK
2Royal National Orthopaedic Hospital, Middlesex HA7 4LP, UK
3Royal Orthopaedic Hospital, Birmingham B31 2AP, UK

Received 14 July 2011; Accepted 5 September 2011

Academic Editor: Umile Longo

Copyright © 2012 S. MacLean et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The use of stems cells in tendon repair is of particular interest given the frequency of tendon injuries worldwide together with the technical difficulty often encountered when repairing or augmenting tendons. Stems cells have the capability to differentiate into a variety of different cell types including osteocytes and tenocytes, and if normal architecture of damaged tendon (either macroscopic or microscopic) could be restored, this would significantly improve the management of patients with these injuries. There is already encouraging research on the use of stems cells clinically although considerable further work is required to improve knowledge and clinical applications of stem cells in tissue engineering.