Endogenous Proliferation after Spinal Cord Injury in Animal Models

Table 1

Summary of studies on the endogenous proliferative response to spinal cord injury.

SCI model	Animal model	Proliferation at		Extent of proliferation		Cell fate of daughter cells	Reference
		Central canal	Parenchyma	Epicenter	Rostral/; caudal
Transection (incision)	Rat	+	Not stated	+	Not stated	Astrocytes	Johansson et al. [8]
Transection (complete)	Rat	+	+	+	Not stated	Macrophages, astrocytes, and OPCs	Yamamoto et al. [28]
Transection (minimal injury)	Rat	+	Not stated	+	−	Astrocytes, Nestin^+ NSCs	Mothe and Tator [29]
Transection (hemisection)	Rat	+	+	−	+	OPCs, OLs, and astrocytes	Horky et al. [30]
Transection (hemisection)	Macaque	Not stated	+	+	+	Macrophages, OPCs, OLs, and astrocytes	Yang et al. [31]
Transection (incision)	Mouse	+	+	+	−	Astrocytes, OPCs	Barnabé-Heider et al. [3]; Meletis et al. [32]
Contusion (weight drop)	Rabbit	+	Not stated	+	+	Not stated	Vaquero et al. [9]; Vaquero et al. [10]
Contusion (NYU impactor)	Rat	+	Not stated	−	+	Not stated	Beattie et al. [1]
Contusion (OSU impactor)	Rat	Not stated	+	+	+	Macrophages, microglia, astrocytes, OPCs, and OLs	McTigue et al. [33]
Contusion (weight drop)	Rat	+	Not stated	+	+	Astrocytes	Takahashi et al. [34]
Contusion (weight drop)	Rat	Not stated	+	+	+	astrocytes, OLs, macrophages, and microglia	Zai et al. [35]
Contusion (weight drop)	Mouse	Not stated	+	+	+	OPCs, astrocytes, OLs, and macrophages	Lytle and Wrathall [36]; Lytle et al. [17]
Compression (clip)	Rat	+	Not stated	+	−	Nestin^+ cells	Namiki and Tator [37]
Compression (clip)	Rat	Not stated	+	+	+	OPCs	Wu et al. [38]