Review Article
The Promise of Human Induced Pluripotent Stem Cells in Dental Research
Table 1
Disease-specific-induced pluripotent stem cells (iPSCs) lines from various human genetic disorders.
| Disease category | Disease | References |
| Neural | Amyotrophic lateral sclerosis | [31] | Parkinson’s disease | [11, 22, 33, 34] | Huntington’s disease | [11, 35] | Lesch-Nyhan syndrome | [11] | Rett syndrome | [36] | Familial dysautonomia | [37] | Angelman syndrome | [38] | Prader-Willi syndrome | [38, 39] | Friedreich’s ataxia | [40] | Rett syndrome | [41] | Schizophrenia | [42] |
| Immune system | ADA-SCID | [11] | Scleroderma | [43] | Primary immunodeficiency | [44] |
| Muscular | Duchenne muscular dystrophy | [11] | Becker muscular dystrophy | [11] | Spinal muscular atrophy | [25] | Duchenne muscular dystrophy | [45] |
| Blood | Thalassemia | [46, 47] | Sickle cell anemia | [43, 47] | Chronic myeloid leukemia | [48] |
| Heart | Long QT syndrome | [49, 50] |
| Pancreas | Juvenile diabetes mellitus | [11] | Shwachman-Bodian-Diamond syndrome | [11] | Type I diabetes | [51] |
| Skin | Leopard syndrome | [52] | Recessive dystrophic, Epidermolysis bullosa | [53] |
| Bone marrow | Fanconi anemia | [54] | Myeloproliferative diseases | [54] |
| Liver | Liver diseases: a1-antitrypsin deficiency, familial hypercholesterolemia, glycogen storagedisease type 1a, Crigler-Najjar, tyrosinemia type 1 | [55] |
| Lung | Lung diseases: cystic fibrosis, a-1 antitrypsin deficiency-related emphysema | [43] |
| Others (physical and intellectual limitations) | Down syndrome | [11] | Hurler syndrome | [44] | Gaucher disease | [11] | Fragile X syndrome | [56] |
| Premature ageing | Dyskeratosis congenital | [57] |
| Eye | Retinitis pigmentosa | [58] | gyrate atrophy | [59] |
| Dental | ? | |
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