High-Resolution Genomic Profiling of Chromosomal Abnormalities in Human Stem Cells Using the 135 K StemArray
Figure 1
The 135 K StemArray has increased probe coverage in stem cell and cancer-associated genes. (a) Stemness gene BUB1 contains 141 total probes resulting in single exon resolution. (b) Exons are covered with 5 probes/exon enabling the detection of a single exon deletion or amplification. (c) In comparison, the standard NimbleGen catalog 135 K array only contains a single probe in the BUB1 gene and therefore does not have the resolution to detect a variation in this gene.
