High-Resolution Genomic Profiling of Chromosomal Abnormalities in Human Stem Cells Using the 135 K StemArray
Figure 4
The stem-cell-targeted 135 K StemArray can detect causative aberrations in iPSC lines known to influence cell survival and proliferation. Detection of two acquired chromosomal abnormalities in stem-cell-associated and cancer-related genes in an iPSC line. (a) A 595 Kb amplification spanning the stem-cell-related DPPA2 and DPPA4 genes, and (b) a 285 Kb deletion covering exons 4-5 of the cancer associated CDH13 gene.
