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Stem Cells International
Volume 2012, Article ID 629230, 6 pages
http://dx.doi.org/10.1155/2012/629230
Review Article

The Potential of iPS Cells in Synucleinopathy Research

1Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany
2Department of Internal Medicine I, Ulm University, 89081 Ulm, Germany

Received 27 October 2011; Accepted 12 January 2012

Academic Editor: Mirella Dottori

Copyright © 2012 Leonhard Linta et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

α-synuclein is a protein involved in the pathogenesis of several so-called synucleinopathies including Parkinson's disease. A variety of models have been so far assessed. Human induced pluripotent stem cells provide a patient- and disease-specific model for in vitro studies, pharmacotoxicological screens, and hope for future cell-based therapies. Initial experimental procedures include the harvest of patients’ material for the reprogramming process, the investigation of the patients genetic background in the cultured cells, and the evaluation of disease-relevant factors/proteins under various cell culture conditions.