Mesenchymal Stromal Cells Do Not Increase the Risk of Viral Reactivation Nor the Severity of Viral Events in Recipients of Allogeneic Stem Cell Transplantation
Figure 1
Frequency of CMV-specific T cells, secreting interferon gamma (IFN-γ) in response to a cocktail of CMV-specific peptides, as measured by ELISPOT assay in two patients reactivating CMV after having received mesenchymal stem cells (MSCs) for the treatment of steroid refractory graft versus host disease. Dotted lines on top of the panels indicate Ganciclovir administration. In the upper panel overall GvHD grading according to NIH criteria is shown. In the central panel Cytomegalovirus (CMV) reactivation trend as measured in copies/milliliter of peripheral blood (PB) is shown. In the lower panel the number of CMV-specific IFN-γ producing cells in relation to MSC infusions as measured in IFN-γ spots/100.000 peripheral blood-mononucleated cells (PBMC) is shown. Black arrows indicate MSC infusions.
