Mesenchymal Stromal Cells Do Not Increase the Risk of Viral Reactivation Nor the Severity of Viral Events in Recipients of Allogeneic Stem Cell Transplantation
Table 1
Patients characteristics.
UPN
Diagnosis
Conditioning regimen
GvHD prophylaxis
GvHD
IS treatment at viral reactivation
1
ALL
TBI + VP16
CSA + MTX + ATG
Acute skin grade II
CSA
4
ALL
TBI + VP16
CSA + MTX + ATG
Acute skin + liver grade III
mPDN, MMF
7
MDS
BU + CY + MEL
CSA + MTX + ATG
Acute gut grade III
mPDN, MMF
9
MNGIE
BU + FLU
CSA + MTX + ATG
Acute gut grade III
mPDN
10
ALL
TBI + VP16
CSA + MTX + ATG
Acute skin grade II
mPDN, CSA
11
AML
BU + CY + MEL
CSA + MTX + ATG
Acute skin + gut + liver grade IV
mPDN, MMF, ETANERCEPT
13
ALL
TREO + FLU
CSA + MTX + ATG
Acute skin grade II
CSA
14
ALL
TT + BU + FLU
CSA + MMF + EDX
Acute gut + liver grade III
mPDN, CSA
15
AML
TREO + FLU
CSA + MTX
Acute Skin + gut + liver grade III
mPDN, CSA
16
ALL
TBI + CY
CSA + mPDN + ATG
Acute gut + liver grade IV
CSA, mPDN, ECP, PENTOSTATIN IMATINIB, CAMPATH
17
AML
BU + CY
CSA + mPDN
Acute gut grade IV
mPDN, CSA
IS: immunosuppression, ALL: acute lymphoblastic leukemia, AML: acute myeloid leukemia, MNGIE: mitocondrial neurogastrointestinal encephalomyopathy, TBI: total body irradiation, BU: busulfan, CY: cyclophosphamyde, MEL: melphalan, TREO: treosulfan, FLU: fludarabine, TT: Thiotepa, CSA: cyclosporine A, MTX: methotrexate, ATG: antithymocyte globulin, mPDN: methylprednisolon, MMF: mofetilmycophenolate, ECP: extracorporeal photopheresis. GvHD is graded according to NIH criteria.
