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Stem Cells International
Volume 2012, Article ID 767195, 7 pages
Review Article

Nonhuman Primate Induced Pluripotent Stem Cells in Regenerative Medicine

1Department of Physiology and Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, 15355 Lambda Drive, San Antonio, TX 78245, USA
2Geriatric Research Education and Clinical Center, South Texas Veterans Healthcare System, San Antonio, TX 78229, USA
3Key Laboratory of Ministry of Education for Protection and Utilization of Special Biological Resources in Western China, and College of Life Science, Ningxia University, Yinchuan, Ningxia 750021, China

Received 16 September 2011; Accepted 27 January 2012

Academic Editor: Rajarshi Pal

Copyright © 2012 Yuehong Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Among the various species from which induced pluripotent stem cells have been derived, nonhuman primates (NHPs) have a unique role as preclinical models. Their relatedness to humans and similar physiology, including central nervous system, make them ideal for translational studies. We review here the progress made in deriving and characterizing iPS cell lines from different NHP species. We focus on iPS cell lines from the marmoset, a small NHP in which several human disease states can be modeled. The marmoset can serve as a model for the implementation of patient-specific autologous cell therapy in regenerative medicine.