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Stem Cells International
Volume 2012, Article ID 823709, 4 pages
http://dx.doi.org/10.1155/2012/823709
Review Article

Advances in MicroRNA-Mediated Reprogramming Technology

Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, BMT-403, Los Angeles, CA 90033, USA

Received 30 November 2011; Revised 26 January 2012; Accepted 27 January 2012

Academic Editor: Rajarshi Pal

Copyright © 2012 Chih-Hao Kuo and Shao-Yao Ying. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Briggs and T. J. King, “Transplantation of living nuclei from blastula cells into enucleated frogs' eggs,” Proceedings of the National Academy of Sciences of the United States of America, vol. 38, pp. 455–463, 1952. View at Google Scholar
  2. K. H. S. Campbell, J. McWhir, W. A. Ritchie, and I. Wilmut, “Sheep cloned by nuclear transfer from a cultured cell line,” Nature, vol. 380, no. 6569, pp. 64–66, 1996. View at Publisher · View at Google Scholar · View at Scopus
  3. K. Takahashi and S. Yamanaka, “Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors,” Cell, vol. 126, no. 4, pp. 663–676, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. T. Aasen, A. Raya, M. J. Barrero et al., “Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes,” Nature Biotechnology, vol. 26, no. 11, pp. 1276–1284, 2008. View at Publisher · View at Google Scholar
  5. J. B. Kim, B. Greber, M. J. Arazo-Bravo et al., “Direct reprogramming of human neural stem cells by OCT4,” Nature, vol. 461, no. 7264, pp. 649–653, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. K. Takahashi, K. Tanabe, M. Ohnuki et al., “Induction of pluripotent stem cells from adult human fibroblasts by defined factors,” Cell, vol. 131, no. 5, pp. 861–872, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. N. M. Kane, S. McRae, C. Denning, and A. H. Baker, “Viral and non-viral gene delivery and its role in pluripotent stem cell engineering,” Drug Discovery Today, vol. 5, no. 4, pp. e107–e115, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. G. Amabile and A. Meissner, “Induced pluripotent stem cells: current progress and potential for regenerative medicine,” Trends in Molecular Medicine, vol. 15, no. 2, pp. 59–68, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. J. B. Kim, H. Zaehres, G. Wu et al., “Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors,” Nature, vol. 454, no. 7204, pp. 646–650, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. L. Warren, P. D. Manos, T. Ahfeldt et al., “Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA,” Cell Stem Cell, vol. 7, no. 5, pp. 618–630, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. G. Tavernier, K. Wolfrum, J. Demeester, S. C. De Smedt, J. Adjaye, and J. Rejman, “Activation of pluripotency-associated genes in mouse embryonic fibroblasts by non-viral transfection with in vitro-derived mRNAs encoding Oct4, Sox2, Klf4 and cMyc,” Biomaterials, vol. 33, no. 2, pp. 412–417, 2012. View at Publisher · View at Google Scholar
  12. M. R. Suh, Y. Lee, J. Y. Kim et al., “Human embryonic stem cells express a unique set of microRNAs,” Developmental Biology, vol. 270, no. 2, pp. 488–498, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Ren, P. Jin, E. Wang, F. M. Marincola, and D. F. Stroncek, “MicroRNA and gene expression patterns in the differentiation of human embryonic stem cells,” Journal of Translational Medicine, vol. 7, article no. 20, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Rosa, F. M. Spagnoli, and A. H. Brivanlou, “The miR-430/427/302 family controls mesendodermal fate specification via species-specific target selection,” Developmental Cell, vol. 16, no. 4, pp. 517–527, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Hohjoh and T. Fukushima, “Marked change in microRNA expression during neuronal differentiation of human teratocarcinoma NTera2D1 and mouse embryonal carcinoma P19 cells,” Biochemical and Biophysical Research Communications, vol. 362, no. 2, pp. 360–367, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. C. Kanellopoulou, S. A. Muljo, A. L. Kung et al., “Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing,” Genes and Development, vol. 19, no. 4, pp. 489–501, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. E. P. Murchison, J. F. Partridge, O. H. Tam, S. Cheloufi, and G. J. Hannon, “Characterization of Dicer-deficient murine embryonic stem cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 34, pp. 12135–12140, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. N. Miyoshi, H. Ishii, H. Nagano et al., “Reprogramming of mouse and human cells to pluripotency using mature microRNAs,” Cell Stem Cell, vol. 8, no. 6, pp. 633–638, 2011. View at Publisher · View at Google Scholar
  19. D. Subramanyam, S. Lamouille, R. L. Judson et al., “Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells,” Nature Biotechnology, vol. 29, no. 5, pp. 443–448, 2011. View at Publisher · View at Google Scholar
  20. S.-L. Lin, D. C. Chang, C.-H. Lin, S.-Y. Ying, D. Leu, and D. T. S. Wu, “Regulation of somatic cell reprogramming through inducible mir-302 expression,” Nucleic Acids Research, vol. 39, no. 3, pp. 1054–1065, 2011. View at Publisher · View at Google Scholar
  21. F. Anokye-Danso, C. M. Trivedi, D. Juhr et al., “Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency,” Cell Stem Cell, vol. 8, no. 4, pp. 376–388, 2011. View at Publisher · View at Google Scholar
  22. S. L. Lin, D. C. Chang, S. Chang-Lin et al., “Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state,” RNA, vol. 14, no. 10, pp. 2115–2124, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. M. L. Stitzel and G. Seydoux, “Regulation of the oocyte-to-zygote transition,” Science, vol. 316, no. 5823, pp. 407–408, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. W. Reik, W. Dean, and J. Walter, “Epigenetic reprogramming in mammalian development,” Science, vol. 293, no. 5532, pp. 1089–1093, 2001. View at Publisher · View at Google Scholar · View at Scopus
  25. A. Rosa and A. H. Brivanlou, “A regulatory circuitry comprised of miR-302 and the transcription factors OCT4 and NR2F2 regulates human embryonic stem cell differentiation,” EMBO Journal, vol. 30, no. 2, pp. 237–248, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. A. Marson, S. S. Levine, M. F. Cole et al., “Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells,” Cell, vol. 134, no. 3, pp. 521–533, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. S. L. Lin, D. C. Chang, S. Y. Ying, D. Leu, and D. T. S. Wu, “MicroRNA miR-302 inhibits the tumorigenecity of human pluripotent stem cells by coordinate suppression of the CDK2 and CDK4/6 cell cycle pathways,” Cancer Research, vol. 70, no. 22, pp. 9473–9482, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. R. Li, J. Liang, S. Ni et al., “A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts.,” Cell stem cell, vol. 7, no. 1, pp. 51–63, 2010. View at Google Scholar · View at Scopus
  29. M. Miyagishi and K. Taira, “U6 promoter-driven siRNAs with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells,” Nature Biotechnology, vol. 20, no. 5, pp. 497–500, 2002. View at Publisher · View at Google Scholar · View at Scopus
  30. N. S. Lee, T. Dohjima, G. Bauer et al., “Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells,” Nature Biotechnology, vol. 20, no. 5, pp. 500–505, 2002. View at Publisher · View at Google Scholar · View at Scopus
  31. C. P. Paul, P. D. Good, I. Winer, and D. R. Engelke, “Effective expression of small interfering RNA in human cells,” Nature Biotechnology, vol. 20, no. 5, pp. 505–508, 2002. View at Publisher · View at Google Scholar · View at Scopus
  32. H. Xia, Q. Mao, H. L. Paulson, and B. L. Davidson, “siRNA-mediated gene silencing in vitro and in vivo,” Nature Biotechnology, vol. 20, no. 10, pp. 1006–1010, 2002. View at Publisher · View at Google Scholar · View at Scopus
  33. S. Gunnery, Y. Ma, and M. B. Mathews, “Termination sequence requirements vary among genes transcribed by RNA polymerase III,” Journal of Molecular Biology, vol. 286, no. 3, pp. 745–757, 1999. View at Publisher · View at Google Scholar · View at Scopus
  34. L. Schramm and N. Hernandez, “Recruitment of RNA polymerase III to its target promoters,” Genes and Development, vol. 16, no. 20, pp. 2593–2620, 2002. View at Publisher · View at Google Scholar · View at Scopus
  35. S. L. Lin, D. Chang, D. Y. Wu, and S. Y. Ying, “A novel RNA splicing-mediated gene silencing mechanism potential for genome evolution,” Biochemical and Biophysical Research Communications, vol. 310, no. 3, pp. 754–760, 2003. View at Publisher · View at Google Scholar · View at Scopus
  36. S. L. Lin, H. Kim, and S. Y. Ying, “Intron-mediated RNA interference and microRNA (miRNA),” Frontiers in Bioscience, vol. 13, no. 6, pp. 2216–2230, 2008. View at Publisher · View at Google Scholar · View at Scopus
  37. S. L. Lin and S. Y. Ying, “Gene silencing in vitro and in vivo using intronic microRNAs,” Methods in Molecular Biology, vol. 342, pp. 295–312, 2006. View at Google Scholar · View at Scopus
  38. H. Zhou, X. G. Xia, and Z. Xu, “An RNA polymerase II construct synthesizes short-hairpin RNA with a quantitative indicator and mediates highly efficient RNAi,” Nucleic Acids Research, vol. 33, no. 6, article e62, 2005. View at Google Scholar · View at Scopus
  39. K. H. Chung, C. C. Hart, S. Al-Bassam et al., “Polycistronic RNA polymerase II expression vectors for RNA interference based on BIC/miR-155,” Nucleic Acids Research, vol. 34, no. 7, article no. e53, 2006. View at Publisher · View at Google Scholar · View at Scopus
  40. S. L. Lin, S. J. E. Chang, and S. Y. Ying, “First in vivo evidence of microRNA-induced fragile X mental retardation syndrome,” Molecular Psychiatry, vol. 11, no. 7, pp. 616–617, 2006. View at Publisher · View at Google Scholar · View at Scopus
  41. S. L. Lin, S. J. Chang, and S. Y. Ying, “Transgene-like animal models using intronic microRNAs,” Methods in Molecular Biology, vol. 342, pp. 321–334, 2006. View at Google Scholar · View at Scopus