Hippocampal Neurogenesis and the Brain Repair Response to Brief Stereotaxic Insertion of a Microneedle
Contribution of blood-derived cells to microgliosis in chimeric mice 2 weeks after lesion placement. (a) Blood-derived GFP+ cells in hippocampal region. (b) Microgliosis two weeks after the lesion is indicated by Iba1 immunoreactivity. (c) Merged images of GFP+ (A) and Iba1+ cells (B). (d) Merged confocal image showing double-labeled microglia (yellow) at a higher magnification. (e) Mean Iba1 and GFP+ signals. On the lesioned side, the mean GFP+ signal is 26% of the total Iba1 signal (ratio of 13.4/51.6). (f) Cells count of double-labeled Iba1/GFP cells is significantly greater on the lesioned side than control.