Optimal Labeling Dose, Labeling Time, and Magnetic Resonance Imaging Detection Limits of Ultrasmall Superparamagnetic Iron-Oxide Nanoparticle Labeled Mesenchymal Stromal Cells
Cellular iron content. The iron content per cell was determined in unlabeled MSC and MSC incubated with half or full dose USPIO for 2, 6, and 21 hours. MSC: mesenchymal stromal cells. USPIO: ultrasmall superparamagnetic iron-oxide. USPIO dose—full: 10 μg per 105 cells; half: 5 μg per 105 cells.