Stem Cells International / 2013 / Article / Tab 2

Research Article

Optimal Labeling Dose, Labeling Time, and Magnetic Resonance Imaging Detection Limits of Ultrasmall Superparamagnetic Iron-Oxide Nanoparticle Labeled Mesenchymal Stromal Cells

Table 2

Cellular iron content.

GroupIron content per cell Multiple comparisons (Bonferroni corrected)
Group AGroup BGroup CGroup DGroup EGroup FGroup G

(A) Unlabeled 0.48 ± 0.17 pg44ns
(B) Half dose, 2 hours incubation1.22 ± 0.52 pg17nsns
(C) Full dose, 2 hours incubation1.54 ± 0.83 pg17ns
(D) Half dose, 6 hours incubation2.36 ± 0.65 pg17ns
(E) Full dose, 6 hours incubation2.71 ± 0.86 pg21
(F) Half dose, 21 hours incubation4.26 ± 1.59 pg37
(G) Full dose, 21 hours incubation5.24 ± 1.50 pg44

Values are shown ± SD.
USPIO: ultrasmall super-paramagnetic iron-oxide. USPIO dose—full = 10  g per 105 cells. half = 5  g per 105 cells, ns: nonsignificant.