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Stem Cells International
Volume 2013, Article ID 361637, 10 pages
Review Article

The Control of Mesenchymal Stromal Cell Osteogenic Differentiation through Modified Surfaces

Biomaterials and Tissue Engineering, Eastman Dental Institute, University College London, 256 Gray’s Inn Road, London WC1X 8LD, UK

Received 19 January 2013; Accepted 2 May 2013

Academic Editor: Gaël Y. Rochefort

Copyright © 2013 Niall Logan and Peter Brett. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Stem cells continue to receive widespread attention due to their potential to revolutionise treatments in the fields of both tissue engineering and regenerative medicine. Adult stem cells, specifically mesenchymal stromal cells (MSCs), play a vital role in the natural events surrounding bone healing and osseointegration through being stimulated to differentiate along their osteogenic lineage and in doing so, they form new cortical and trabecular bone tissue. Understanding how to control, manipulate, and enhance the intrinsic healing events modulated through osteogenic differentiation of MSCs by the use of modified surfaces and biomaterials could potentially advance the fields of both orthopaedics and dentistry. This could be by either using surface modification to generate greater implant stability and more rapid healing following implantation or the stimulation of MSCs ex vivo for reimplantation. This review aims to gather publications targeted at promoting, enhancing, and controlling the osteogenic differentiation of MSCs through biomaterials, nanotopographies, and modified surfaces for use in implant procedures.