Modelling Human Channelopathies Using Induced Pluripotent Stem Cells: A Comprehensive Review
Figure 1
Schematic delineation of the cardiac action potential—resting “4,” upstroke “0,” early repolarization “1,” plateau “2,” and final repolarization “3.” Inward currents: and . Delayed rectifier currents: , . Inward rectifier currents: , . Adapted from [3]: (a) normal cardiac action potential. Different currents are allocated to their chronology in the AP course. Ion channel genes are written semitransparent. (b) Different LQTSs are shown in relation to their distinct ion current causative for the indicated syndrome. Overactivation/reduction of different currents leads to a significant elongation of the action potential.
