Autologous Bone Marrow Mononuclear Cell Therapy for Autism: An Open Label Proof of Concept Study

Table 3

Change in the ISAA scores of individual domains measured before and after intervention.

ISAA scale domain	Median score before cellular transplantation	Median score after cellular transplantation	Test statistics of Wilcoxon signed rank test for matched pairs	Statistical significance
Social relationship and reciprocity	35.5	13	−4.118	𝑃<0.001^∗
Emotional responsiveness	23	20	−3.153	𝑃=0.002^∗
Speech, language, and communication	13	11	−3.989	𝑃<0.001^∗
Behavior patterns	29	10	−3.126	𝑃=0.002^∗
Sensory aspects	21	17	−2.409	𝑃=0.016^∗
Cognitive component	11	8	−3.508	𝑃<0.001^∗

∗Statistically significant (level of significance at 𝑃<0.05).