Review Article
Cellular Kinetics of Perivascular MSC Precursors
Table 1
The influence of ECs on the multipotency of tissue-specific MSCs.
| Niche Component | Model | Stem cell surrogate | Niche surrogate | Lineage assessed | Effect on differentiation | Context | Proposed mechanism | Investigator |
| Endothelial cell | 3D | ASC | HUVEC | Osteogenesis | ↓ | Paracrine | ↑Wnt | Rajashekhar et al. [187] | Endothelial cell | 3D | ASC | HUVEC | Osteogenesis | ↓ | Juxtacrine | ↑Wnt | Rajashekhar et al. [187] | Endothelial cell | 2D | BMSC | HUVEC | Osteogenesis | ↑ | Paracrine | (Dkk1-Wnt, FGF, PDGF, BMP, TGFβ, Notch) | Saleh et al. [188] | Endothelial cell | 2D | BMSC | HUVEC | Adipogenesis | — | Paracrine | — | Saleh et al. [189] | Endothelial cell | 2D | BMSC | HUVEC | Osteogenesis | ↑ | Juxtacrine | — | Xue et al. [190] | Endothelial cell | 2D | BMSC | HDMEC | Osteogenesis | ↑ | Juxtacrine | BMP-2 | Kaigler et al. [191] | Endothelial cell | 2D | BMSC | HDMEC | osteogenesis | — | Paracrine | — | Kaigler et al. [191] | Endothelial cell | 2D | BMSC | HDMEC | Osteogenesis | ↑ | Juxtacrine | N-cadherin | Li et al. [192] | Endothelial cell | 2D | BMSC | HDMEC | Osteogenesis | ↑ | Paracrine | VEGF | Grellier et al. [193] | Endothelial cell | 2D | BMSC | HDMEC | Osteogenesis | ↓ | Paracrine | Osterix/OSX | Meury et al. [194] | Endothelial cell | 2D | BMSC | HUVEC | Osteogenesis | ↑ | Juxtacrine | Cx43/gap junctions | Villars et al. [195] | Endothelial cell | 2D | BMSC | HUVEC | Osteogenesis | ↑ | Juxtacrine | — | Villars et al. [196] | Endothelial cell | 2D | HOP | HUVEC | Osteogenesis | ↑ | Juxtacrine | — | Guillotin et al. [197] | Endothelial cell | 2D | HOP | EPC, HSVEC | Osteogenesis | ↑ | Juxtacrine | Cx43/gap junctions | Guillotin et al. [197] |
|
|