Reducing TRPC1 Expression through Liposome-Mediated siRNA Delivery Markedly Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension in a Murine Model

Figure 10

mRNA expressions of fibrotic and apoptotic biomarkers in lung parenchyma and right ventricle (RV) by day 28 after hypoxia-induced pulmonary arterial hypertension (PAH) (). ((a) to (d)) mRNA expressions of (a) β-myosin heavy chain (MHC), (b) α-MHC, (c) caspase-3, and (d) Bax in RV myocardium. versus other groups with different symbols (, †, ‡), all values in ((a) to (d)) <0.001. ((e) to (h)) mRNA expressions of (e) endothelial nitric oxide synthase (eNOS), (f) endothelin (ET-1), (g) tumor necrotic factor (TNF)-1α, and (h) matrix metalloproteinase- (MMP-) 9 in lung tissues. versus other groups with different symbols (, †, ‡), all values in ((e) to (h)) <0.001. Statistical analysis in ((a) to (h)) using one-way ANOVA, followed by Bonferroni multiple comparison post hoc test. Symbols (, †, ‡) indicate significance (at 0.05 level).

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