Reducing TRPC1 Expression through Liposome-Mediated siRNA Delivery Markedly Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension in a Murine Model

Figure 7

Protein expressions of TRPCs, HIF-1α, and VEGF of lung parenchyma by day 28 after hypoxia-induced pulmonary arterial hypertension (PAH) (). (a) Protein expression of TRPC1, versus other groups with different symbols (, †, ‡), . (b) Protein expression of TRPC4, versus other groups with different symbols (, †, ‡), . (c) Protein expression of TRPC6, versus other groups with different symbols (, †, ‡), . (d) Protein expression of HIF-1α, versus other groups with different symbols (, †, ‡), . (e) Protein expression of vascular endothelial growth factor (VEGF), versus other groups with different symbols (, †, ‡), . Statistical analysis in ((a) to (e)) using one-way ANOVA, followed by Bonferroni multiple comparison post hoc test. Symbols (, †, ‡) indicate significance (at 0.05 level).

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