Reducing TRPC1 Expression through Liposome-Mediated siRNA Delivery Markedly Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension in a Murine Model

Figure 8

Protein expressions of fibrotic and antifibrotic biomarkers of lung parenchyma by day 28 after hypoxia-induced pulmonary arterial hypertension (PAH) (). (a) Protein expression of transforming growth factor (TGF-β), versus other groups with different symbols (, †, ‡), . (b) Protein expression of phosphorylated- (P-) Smad3, versus other groups with different symbols (, †, ‡), . (c) Protein expression of bone morphogenetic protein- (BMP-) 2, versus other groups with different symbols (, †, ‡), . (d) Protein expression of phosphorylated- (P-) Smad1/5, versus other groups with different symbols (, †, ‡), . Statistical analysis in ((a) to (d)) using one-way ANOVA, followed by Bonferroni multiple comparison post hoc test. Symbols (, †, ‡) indicate significance (at 0.05 level).

(a)

(b)

(c)

(d)