Reducing TRPC1 Expression through Liposome-Mediated siRNA Delivery Markedly Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension in a Murine Model

Figure 9

Protein expressions of apoptotic and DNA repair biomarkers in lung parenchyma by day 28 after hypoxia-induced pulmonary arterial hypertension (PAH) (). (a) Protein expressions of cleaved caspase-3 (c-Csp3), versus other groups with different symbols (, †, ‡), . (b) Protein expression of cleaved poly(ADP-ribose) polymerase (c-PARP), versus other groups with different symbols (, †, ‡), . (c) Protein expression of mitochondrial Bax (mito-Bax), versus other groups with different symbols (, †, ‡), . (d) Protein expression of Ku-70, versus other groups with different symbols (, †, ‡), . Statistical analysis in ((a) to (d)) using one-way ANOVA, followed by Bonferroni multiple comparison post hoc test. Symbols (, †, ‡) indicate significance (at 0.05 level).

(a)

(b)

(c)

(d)